Module 5: Target Organ Toxicity and Biomarkers
Date of release/last update: created 22-04-2016, last version 3-12-2017
Authors
- Ana Isabel Morales Martín (USAL)
- Marta Prieto Vicente (USAL)
- Laura Vicente Vicente (USAL)
- Moisés Pescador Garriel (USAL)
- Alfredo Ginés Casanova Paso (USAL)
- Premysl Mladenka (CUNI)
- Jana Pourova (CUNI)
- Fernando Remião (UPorto)
- Ana Rita Lima (UPorto)
- Daniela Rodrigues (U.Porto)
- Carolina Rocha-Pereira (U.Porto)
- Ricardo Dinis-Oliveira (U.Porto)
- Helena Carmo (UPorto)
- Félix Carvalho (UPorto)
- Maria de Lourdes Bastos (UPorto)
Short descriptions
This module aims to learn the adverse effects or pathological states caused by toxicants in specific organs of the body. For each organ, several aspects will be discussed: the main mechanisms involved in the toxicity, the main toxicants responsible for the damage and the currently used biomarkers which are able to specify the kind of damage and the place where is being produced.
Intended learning outcomes
- At the end of this module, the learner should be able to:
- identify the organ and type(s) of damage brought by toxic agents.
- know the mechanisms of toxicity produced in each organ.
- differentiate the biomarkers able to detect the damage(s) in
each organ.
For each target organ of toxicity, the student should be familiar with:
- Important information about the structure and function of
organs if relevant for toxicologal aspects
- General patterns of organ toxicity including mechanisms of
damage (if known)
- Consequences of organ toxic damage(s), in particular
functional impairment
- Important biomarkers of organ toxicity (if known)
- Important consequences of organ toxicity affecting other
tissues or systems (if they exist)
- Examples of toxic substances that affect the target organ
Module structures
5.1 Cardiovascular toxicity (2 ECTS)
- Basic aspects of the heart physiology including the impact
of the sympathetic and parasympathetic nervous system
- An overview of cardiovascular toxicity including the most
important toxic agents and main modalities of intoxications treatment
- Markers of cardiovascular toxicity
5.2 Pulmonary toxicity (1 ECTS)
- Human respiratory system anatomy, physiology and defence -
basic aspects
- Air-borne agents - general characteristics and the most
important toxic gases, vapors and fine particles
- Blood-borne agents - general characteristics and the most important examples
5.3 Renal toxicity (2 ECTS)
- Renal system and sources of exposure to renal toxins
- Mechanisms of nephrotoxicity
- Kidney response to toxic injury
- Diagnosis and treatment of kidney damage
5.4 Liver toxicity (2 ECTS)
- Liver physiology
- Main mechanisms of liver injury by xenobiotics
- Factors affecting xenobiotic hepatotoxicity
- Hepatotoxic xenobiotics (e.g. alcohol, paracetamol, carbon tetrachloride, aflatoxin B)
5.5 Nervous system toxicity (1 ECTS)
- Nervous system
- Toxic neuropathies
- Neurodegenerative diseases and toxicity
Estimated workload
8 ECTS: 224 hours
Audience
Students (University, PhD or Master) of degrees:
- Pharmacy
- Medicine
- Nursing
- Veterinary medicine
- Biology
- Environmental Engineering
- Forensic sciences
Students of Vocational training
- Pharmacy assistant
- Nursing assistant
- Veterinary assistant
- Laboratory technicians
Professionals in fields related to toxicology
- Pharmacists
- Occupational medicine professionals
- Forensics
- Supervisory bodies
- Police forces
General audience interested in toxicology
Available languages
English, Spanish, Portuguese, Italian, Czech, Romanian, Bulgarian, Finnish
First, an English or native language version of each author will be created. Translations into the languages of all involved countries and English will be the final outcome.
![](http://moodle.toxoer.com/pluginfile.php/428/course/overviewfiles/2011_Heart_Valves.jpg)
- Profesor: Lenka Applova
- Profesor: Premysl Mladenka
- Profesor: Jana Pourova
- Profesor: Marie Voprsalova
![](http://moodle.toxoer.com/pluginfile.php/433/course/overviewfiles/Pulmonary_Hypertension.png)
- Profesor: Lenka Applova
- Profesor: Premysl Mladenka
- Profesor: Jana Pourova
- Profesor: Marie Voprsalova
![](http://moodle.toxoer.com/pluginfile.php/438/course/overviewfiles/renal.jpg)
- Profesor: Alfredo G. Casanova
- Profesor: María Teresa Hernández
- Profesor: Ana Morales
- Profesor: Moisés Pescador
- Profesor: Marta Prieto
- Profesor: Laura Vicente
![](http://moodle.toxoer.com/pluginfile.php/448/course/overviewfiles/14760521461_77c42b056b_b.jpg)
- Profesor: Alfredo G. Casanova
- Profesor: María Teresa Hernández
- Profesor: Ana Morales
- Profesor: Moisés Pescador
- Profesor: Marta Prieto
- Profesor: Laura Vicente